Pehea e pale ai i nā maʻi autoimmune

Nānā Ka wānana a me ka pale ʻana i nā maʻi autoimmune: nā ʻano ʻē aʻe o ka mosaic o ka autoimmunity D Shepshelovich et al. Lupus. 2006.

ʻĀpana

ʻO nā maʻi pili kino autoimmune he mau maʻi, hiki ke hoʻoweliweli i ke ola i nā maʻi multisystem paʻakikī. ʻAʻole ʻike ʻia kā lākou etiology akā he mea nui ka genetic, hormonal a me nā mea pili i ke kaiapuni. ʻO ka maʻi maʻi ma mua o kahi manawa lōʻihi (i kekahi manawa he mau makahiki) ke ʻike ʻia nā mea maʻi e nā antibodies i loko o kā lākou serum. Ke ʻike ʻia kēlā maʻi e hahai mau ʻia ʻo ia a mālama ʻia inā ʻike ʻia ka maʻi maʻi. Eia nō naʻe, ʻo nā kumu ʻē aʻe ma waho o ka loaʻa ʻana o nā autoantibodies he waiwai wānana no kēlā mau maʻi; ʻO kekahi o lākou he hoʻoilina a i ʻole genetic, a hiki ke hoʻohana wale ʻia e wānana i ka hiki ʻana mai o ka maʻi e hiki mai ana, a ʻo nā mea ʻē aʻe, pili i ka nohona a me ke kaiapuni, hiki ke hoʻololi ʻia i mea e hoʻāʻo ai a pale aku. Ua hōʻike ʻia kekahi mau haʻawina liʻiliʻi liʻiliʻi ʻole e hiki ke pale ʻia ka maʻi autoimmune inā mālama ʻia me ka ikaika ma mua o ka hōʻike ʻana o nā hōʻailona. Eia nō naʻe, inā pēlā, pono e hoʻopaʻa ʻia nā pae hoʻohālikelike no ke koho ʻana i nā maʻi no kēia mālama pale. ʻO nā poʻe maʻi wale nō i ʻoi aku ka kiʻekiʻe o ka ulu ʻana o ka maʻi maʻi a laila pono e mālama ʻia kekahi paepae ʻoiai asymptomatic. ʻO ka pahuhopu o kēia ʻatikala e nānā i nā kumu koʻikoʻi nui no ka maʻi autoimmune, ʻo ka hoʻoilina a me ke kaiapuni, a no laila e kōkua i ka wehewehe ʻana i kēlā mau koina e hiki mai ana. Pono e ʻōlelo ʻia ka poʻe i pilikia i ka hoʻomohala ʻana i kahi maʻi autoimmune e hōʻole i nā hana a me ke ʻano o ka nohona e hoʻoweliweli i ko lākou olakino a me ka maikaʻi o ke ola.

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He kumuhana “wela” i ka lāʻau lapaʻau ʻo Inflammation.

Hoʻopili ʻia ia i nā maʻi maʻi āpau i ʻike ʻia – mai ka maʻi puʻuwai a hiki i ka maʻi kanesa, ka maʻi maʻi i ka momona, ka autism i ka dementia, a me ke kaumaha. ʻO nā maʻi ʻeha ʻē aʻe e like me nā allergies, asthma, arthritis, a me nā maʻi autoimmune ke piʻi nui nei. Ma ke ʻano he kauka, ua aʻo ʻia mākou e pani i ka mumū me ka aspirin, nā lāʻau anti-inflammatory e like me Advil a i ʻole Motrin, steroids, a me ka ʻoi aku ka ikaika o ka pale ʻana i nā lāʻau me nā hopena koʻikoʻi. Akā,ʻaʻole mākou i aʻoʻia eʻimi a mālama i nā kumu kumu o ka mumū i ka maʻi maʻi. ʻO nā allergens huna, nā maʻi, nā toxins kaiapuni, kahi meaʻai inflammatory, a me ke kaumaha ke kumu maoli o kēia mau maʻi inflammatory. ʻO nā maʻi autoimmune, kūikawā, i kēia manawa e pili ana i ka 24 miliona mau kānaka a me ka rheumatoid arthritis, lupus, multiple sclerosis, thyroid disease, inflammatory bowel maʻi, a me nā mea hou aku. Hoʻopiʻi pinepine ʻia kēia mau mea e ka lāʻau hoʻopaʻa i ka immune ikaika a ʻaʻole ma ka hoʻoponopono ʻana i ke kumu. Ua like ia me ka lawe nui ʻana i ka aspirin oiai ʻoe e kū ana ma kahi pā. ʻAʻole ʻoi aku ka nui o ka aspirin a i ʻole ka hoʻopaʻa ʻana i ka immune ikaika, akā e wehe ana i ka tack. Inā makemake ʻoe e hoʻomaʻalili i ka ʻāʻī o ke kino, pono ʻoe e ʻimi i ke kumu. E mālama i ke ahi, ʻaʻole i ka uahi. I ka lāʻau lapaʻau, ua aʻo nui ʻia mākou e ʻike i ka maʻi ma nā hōʻailona, ʻaʻole ma muli o ko lākou kumu kumu. ʻO ka lāʻau lapaʻau hana, ka mea e puka mai nei ka 21st century paradigm o nā lāʻau lapaʻau ʻōnaehana, aʻo iā mākou e mālama i ke kumu, ʻaʻole wale nā hōʻailona, e nīnau i ka nīnau no ke aha ʻoe i maʻi ai, ʻaʻole wale ka maʻi āu i loaʻa ai. Ua komo koke wau i kahi kūkākūkā hui me ke kauka maʻamau, he rheumatologist, a me ka mea maʻi me kahi maʻi autoimmune, a me kekahi o kaʻu mau maʻi i hoʻōla ʻia i kahi maʻi autoimmune paʻakikī ma ka hoʻoponopono ʻana i nā kumu. ʻO ka manaʻo o nā kauka ʻē aʻe, ʻo ia ka mea e hoʻopau ai i ka mumū me ka lāʻau lapaʻau, ʻaʻole ʻike a mālama i ke kumu. ʻO ka lāʻau lapaʻau hana he ʻano noʻonoʻo ʻē aʻe e pili ana i ka maʻi e kōkua iā mākou e hoʻomaopopo a mālama i nā kumu maoli o ka mumū ma mua o ka ʻimi ʻana i nā ala akamai e pani ai. ʻO ka lāʻau lapaʻau e like me ka hoʻomaʻamaʻa ʻana i kēia mau lā, ua like ia me ka lawe ʻana i ka pā uila mai kahi mea ʻike uahi a ʻā ke ahi i kou hale! Hoʻopili ʻia nā kūlana autoimmune e hoʻokahi kaʻina biochemical koʻikoʻi: ʻO kahi pane pale pale i ʻike ʻia ʻo ia hoʻi ʻo ka ʻona ʻōnaehana e hopena i kou kino e hoʻouka i kāna mau kiko ponoʻī. I ka wehewehe ʻana o koʻu mea maʻi i kona hoʻōla ʻana i kāna maʻi autoimmune ma o ka ʻimi ʻana a me ka hoʻopau ʻana i nā kumu o ka mumū i kāna meaʻai a me kāna kaiapuni, ua hoʻokuʻu ʻia ʻo ia ma ke ʻano he “kala kala ʻole.” I ke alo o kahi maʻi lapaʻau e hoʻohaʻahaʻa i ka paradigm, ʻaʻole ʻike kēia mau kauka a hoʻokuʻu koke, e wehewehe ana i ka mea i kaʻana like me anecdotal. ʻO koʻu mea maʻi ma kēlā papa, he makua kāne paʻakikī 46 makahiki o ʻekolu, ua wela loa ʻo ia i hiki ʻole ke hana. Ma ka mālama ʻana i nā kumu kumu o kona ʻāʻī, aia ʻo ia i ke olakino maikaʻi, hauʻoli i kona ola me kāna mau keiki a hiki iā ia ke mālama pono iā lākou. ʻO nā moʻolelo e like me kēia (a me nā mea ʻē aʻe he nui aʻu i hōʻike ai ma kaʻu blogs, puke, a ma ke kīwī) ʻaʻole ia he moʻolelo moʻolelo akā he panana nunui e kuhikuhi ana iā mākou i ke ala e pono ai mākou e ʻimi e loaʻa nā pane i nā pilikia olakino. Ma ka moʻomanaʻo o kēia lā, e wehewehe wau i ke ʻano o ka autoimmunity, pehea ka ʻaʻa ʻana o ka mumū i waho o ka mana, e wehewehe i kekahi o nā kumu kumu o kēia mau ahi i loko o ke kino, a hāʻawi iā ʻoe i ʻeiwa mau ʻanuʻu e hoʻomaʻalili i ke ahi o ka mumū a lanakila i nā kūlana mai nā allergies. i ka arthritis a me nā mea hou aku.

Autoimmunity: He aha ia a pehea e hana ai

Ke kū nei mākou i kahi maʻi maʻi maʻi (60 miliona mau kānaka), asthmatic (30 miliona mau kānaka), a me nā maʻi autoimmune (24 miliona mau kānaka). ʻO nā maʻi autoimmune ka maʻi rheumatoid, lupus, multiple sclerosis, psoriasis, celiac maʻi, thyroid maʻi, a me nā maʻi maʻi paʻakikī ʻē aʻe i ka 21st century. ʻO kēia nā kūlana autoimmune āpau, a ma ko lākou aʻa ua hoʻopili ʻia lākou e hoʻokahi kaʻina biochemical kikowaena: ʻO kahi pane pale pale i ʻike ʻia ʻo ia hoʻi ʻo ka ʻona ʻōnaehana e hopena i kou kino e hoʻouka i kona mau kiko ponoʻī. ʻO kou ʻōnaehana pale kou pale aku i nā mea hoʻouka kaua. ʻO kou pūʻali koa i loko a pono e hoʻokaʻawale i ka hoaaloha mai ka ʻenemi – e ʻike iā ʻoe mai nā poʻe ʻē aʻe. Loaʻa ka autoimmunity i ka wā e huikau ai kāu ʻōnaehana pale a loaʻa kāu mau ʻiʻo ponoʻī i ke ahi keʻa aloha. Ke hakakā nei kou kino i kekahi mea – he maʻi, he ʻawaʻawa, he allergen, meaʻai a i ʻole ka pane ʻana i ke kaumaha – a i kekahi manawa e hoʻihoʻi hou ʻo ia i kāna hoʻouka kaua ʻana i kou mau ami, kou lolo, kou thyroid, kou ʻōpū, kou ʻili, a i kekahi manawa kou kino holoʻokoʻa. . Loaʻa kēia huikau immune mai ka mea i kapa ʻia ʻo ka mimicry molecular. ʻAʻole loaʻa i nā ʻano hana maʻamau ke ʻano no ka ʻimi ʻana i ka hōʻino i kumu i ka pilikia. Hāʻawi ka lāʻau lapaʻau i kahi palapala ʻāina e ʻike ai i ka moleke e hoʻohālike nei nā cell. ʻO ka mea e mahalo ai, hiki ke loaʻa nā maʻi autoimmune i nā ʻāina i kūkulu ʻia. ʻAʻole loaʻa kēia mau maʻi i ka poʻe ma nā ʻāina ʻilihune me ka ʻole o nā pono o kēia wā e like me ka wai kahe, nā hale ʻauʻau ʻauʻau, nā mīkini holoi, a me nā pā hale ʻole. Inā ua ulu ʻoe ma kahi mahiʻai me nā holoholona he nui, ʻaʻole ʻoe e loaʻa i kekahi o kēia mau maʻi ʻeha. ʻO ka pāʻani ʻana i ka lepo, ka lepo, a me ka ʻike ʻana i nā pōpoki a me nā maʻi e hoʻomaʻamaʻa i kou ʻōnaehana pale e ʻike i ka mea ʻē aʻe a he aha “ʻoe.” I kēia ʻāina, ʻo nā maʻi autoimmune, i ka wā i hui pū ʻia, he kaumaha nui ke olakino. ʻO lākou ka ʻewalu kumu nui o ka make ma waena o nā wahine, e hōʻemi ana i ka awelika o ke ola o ka mea maʻi i ʻewalu makahiki. ʻO ke kumukūʻai mālama ola olakino no nā maʻi autoimmune he $120 biliona i kēlā me kēia makahiki e hōʻike ana ma kahi o ʻelua ʻelua o ke kaumaha mālama ola kino o ka maʻi kanesa (ma kahi o $70 biliona o ka makahiki). (i) ʻO ka mea pōʻino, hiki i ka nui o nā lāʻau lapaʻau maʻamau ke hōʻeha iā ʻoe. ʻO nā lāʻau lapaʻau anti-inflammatory e like me Advil, steroids, immune suppressants like methotrexate, a me nā mea hou TNF-alpha blockers e like me Enbrel a Remicade hiki ke alakaʻi i ke kahe o ka ʻōpū, ka hōʻino ʻole ʻana, ke kaumaha, psychosis, osteoporosis, nalo nā ʻiʻo, a me ka maʻi diabetes, ʻaʻole e haʻi i ka nui. ka ma’i a me ka ma’i ‘a’ai.(ii) Ke hoʻohana koho ʻia kēia mau lāʻau lapaʻau hiki ke kōkua i ka poʻe e hoʻihoʻi i ko lākou ola. Akā ʻaʻole lākou he hopena lōʻihi. ʻAʻole pono lākou ka hopena o ka mālama ʻana, akā he alahaka e hoʻomaha ai i ka ʻāʻī ʻoiai mākou e mālama i ke kumu kumu o ka maʻi. Aia kekahi ala e hoʻoponopono ai i nā kūlana autoimmune. E kaʻana like iaʻu i ka moʻolelo like aʻu i haʻi aku ai i nā kauka ma kēlā papa.

Hoʻihoʻi ʻana mai Autoimmunity: Hoʻoponopono i nā kumu kumu o ka ʻā

Ua hoʻopau koʻu maʻi ʻo Sam i kahi pōʻino lōʻihi ma o ka ʻōnaehana olakino ma mua o kona hele ʻana e ʻike iaʻu. No nā makahiki, hele ʻo ia mai ke kauka a i ke kauka e kiʻi i nā ʻano lepili āpau no kona mau pilikia akā ʻaʻohe kōkua maoli i ka mālama ʻana iā lākou. Ua hoʻomohala koke kēia ʻoihana paʻakikī paʻakikī i kahi ʻano o nā maʻi ʻeha e like me nā maʻi sinus a me nā maʻi prostate. Nui nā kauka i hāʻawi iā ia i nā lāʻau antibiotic no kēia mau maʻi. Ma hope koke iho, ua loaʻa ʻo ia i ka ʻeha nui o ka umauma a hele i ke keʻena pilikia. ʻOiai ʻo ia ma laila, ua ʻike nā kauka i ka pehu o nā lymph nodes a haʻi iā ia he lymphoma kona, he ʻano maʻi kanesa. No ʻekolu pule ua noho ʻo ia me ke kaumaha a hiki i ka hoʻi ʻana mai o nā hopena biopsy. Ua ʻike ʻia ʻaʻohe ona maʻi kanesa akā he maʻi autoimmune. ʻO wai ka maʻi autoimmune? ʻAʻole maopopo loa nā kauka… Ua loaʻa iā ia nā hopena hoʻāʻo koko he nui – e like me ke koko keʻokeʻo haʻahaʻa a me ka helu platelet, kiʻekiʻe kiʻekiʻe o nā auto-antibodies o nā ʻano āpau (antibodies e hoʻouka i kā mākou mau kiko ponoʻī), immunoglobulins kiʻekiʻe (nā koa wāwae o ka ʻōnaehana immune), a me autoimmune thyroid. maʻi maʻi. Akā ua paʻakikī nā kauka e kau i ko lākou manamana lima i ka hewa. ʻAʻole hiki iā lākou ke hōʻailona iā ia. I kēia manawa, ua hoʻomohala ʻo Sam i ka metabolic syndrome a me ka loaʻa ʻana o ke kaumaha (pre-diabetes) ma muli o ka holo holo ʻana o kona kino. Eia kahi ʻōlelo mai kekahi o kāna mau moʻolelo kūikawā:

“Inā loaʻa iā ia ka lupus a i ʻole Sjogren’s syndrome ʻaʻole maopopo. Eia naʻe, pono wale ʻo ia i ka nānā ʻana a ʻaʻohe hana therapeutic i kēia manawa. ”

He mea maʻamau kēia. He aha kā lākou i manaʻo ai e nānā, pehea kona manaʻo? A i ʻole e kali wale lākou iā ia e ʻoi aku ka ʻino ma mua o ke komo ʻana? ʻO ia ka manawa i hele mai ai iaʻu. Ke hoʻohana nei i kahi ala lapaʻau hana, kahi ala hou o ka noʻonoʻo e pili ana i nā kumu kumu a me nā hemahema o ka maʻi maʻi, hoʻomaka wau ma ka nīnau ʻana iā Sam i kekahi mau nīnau maʻalahi. A laila hele au i ka ʻimi ʻana i nā toxins, allergens, a me nā maʻi maʻi – nā kumu maʻamau āpau o ka mumū – a ʻike i nā kumu maoli o kāna mau hōʻailona. Ua lawe ʻo ia i nā lāʻau lapaʻau he nui i hoʻololi i kāna pua a i ʻole bacteria a hoʻonui i ka ulu ʻana o ka hū. Ua ulu aʻela ka haʻihaʻi a me ka hū i loko o kona kino, e ulu ana ma waena o kona manamana wāwae, ma kona manamana wāwae, ma kona ʻāʻī, a me ka ʻili poʻo. Loaʻa iā ia ka bacteria Helicobacter pylori i loko o kona ʻōpū. Ua loaʻa iā ia kahi ʻōpū leaky a pane aku i nā meaʻai he nui, me ka waiu a me ka gluten. Ua ʻike ʻia ʻo ia i nā toxins ma kāna hana a he kiʻekiʻe kiʻekiʻe o ka mercury. A ua loaʻa iā ia nā maʻi sinus mau. No laila, hele mākou i ka hana hoʻomaʻemaʻe hale. Ua mālama au i kāna mea hū me nā anti-fungals a me ka H. pylori me nā lāʻau lapaʻau, hoʻopau i kāna mau meaʻai, hoʻoponopono i kona ʻōpū, hoʻomaʻemaʻe iā ia mai nā metala a hoʻomaʻemaʻe i kāna sinuses. A laila ua kōkua au e hoʻōla i kona ʻōnaehana pale ma ke kākoʻo ʻana iā ia me nā meaʻai. Hāʻawi wau iā ia i ka zinc, ka aila iʻa, ka huaʻa D, nā mea kanu, a me nā probiotics, a kau iā ia i kahi meaʻai maʻemaʻe, ʻai holoʻokoʻa, allergen-free, anti-inflammatory meaʻai. I kāna huakaʻi hele hou aku, ua nīnau au iā Sam pehea ʻo ia, me ka manaʻo e ʻōlelo ʻo ia ua maikaʻi iki kona manaʻo. Eia naʻe, kāhāhā nō hoʻi iaʻu kāna pane. Ua ʻōlelo ʻo ia ua maikaʻi ʻo ia. “Pehea ka luhi?” Ninau au. “He ikaika nui koʻu.” “Pehea e pili ana i ka pehu a me ke kinoea?” “ʻAʻole.” “Pehea ka reflux?” “Ua hala.” “Pehea kāu sinuses a me ka phlegm mau?” “Akaka nā mea a pau.” “Pehea e pili ana i kou pilikia hoʻomanaʻo a me ka noʻonoʻo ʻana?” “Maikaʻi nā mea a pau.” A lilo ʻo ia i 15 paona. I ka hiki ʻana mai o kāna labs, ua hōʻoia lākou i kāna mea i haʻi mai iaʻu – ua hoʻi lākou a pau i ka maʻamau. Ua hoʻonui ʻia kona mau keʻokeʻo keʻokeʻo a ua mālie kona mau hōʻailona pale. Hōʻike wale nā hualoaʻa a Sam i ka hoʻohana ʻana i kahi kumu hoʻohālike hou o ka noʻonoʻo e pili ana i nā pilikia i kapa ʻia ka lāʻau lapaʻau hana — he ala ia e hele ai i ke kumu o nā pilikia olakino a mālama i nā kumu kumu o nā mea e pilikia ai ʻoe ma mua o ke kāohi ʻana i nā hōʻailona me nā lāʻau lapaʻau. Inā loaʻa iā ʻoe kahi maʻi autoimmune, eia kāu mea e noʻonoʻo ai a hana.

ʻEiwa mau ʻanuʻu no ka mālama ʻana i ka maʻi autoimmune

E nānā i nā maʻi huna – hū, virus, bacteria, Lyme, etc. – me ke kōkua o ke kauka, a mālama iā lākou.
E nānā i nā mea ʻai huna me ka hoʻāʻo ʻana i ka meaʻai IgG a i ʻole e hoʻāʻo wale ʻO ka UltraSimple Diet , i hoʻolālā ʻia e hoʻopau i ka hapa nui o nā meaʻai.
E hoʻāʻo ʻia no ka maʻi celiac, ʻo ia ka hoʻāʻo koko e hiki i kekahi kauka ke hana.
E hoʻopaʻa ʻia no ka ʻawaʻawa metala kaumaha. Hiki i ka Mercury a me nā metala ʻē aʻe ke kumu i ka autoimmunity.
E hoʻoponopono i kou ʻōpū. No nā kikoʻī, e ʻike i kaʻu blog ma ka irritable bowel syndrome.
E hoʻohana i nā meaʻai e like me ka aila iʻa, ka huaora C, ka huaora D, a me nā probiotics e hoʻomaha i kou pane kūlohelohe.
E hoʻoikaika kino mau — he mea hoʻomake maoli.
E hoʻomaʻamaʻa i ka hoʻomaha hohonu e like me ka yoga, ka hanu hohonu, ka biofeedback, a i ʻole ka lomilomi, no ka mea, ʻoi aku ka nui o ke kaumaha i ka pane ʻana o ke kino.
E haʻi i kāu kauka e pili ana i ka Lapaʻau Hana Hana a paipai iā ia e hoʻomaʻamaʻa – e hele i functionalmedicine.org no ka ʻike hou aku a e kiʻi i kope o ka puke no ka Lapaʻau Hana Hana.

E ho’āʻo i kēia mau ʻanuʻu – a ʻike inā ʻaʻole ʻoe e hoʻomaka i ka emi ʻana o ka wela. E like me kaʻu i ʻōlelo ai ma mua, aia nā pane i mua ou. E mālama i nā kumu kumu o kou maʻi a hoʻomaka ʻoe e ʻike hou i ke olakino olakino. Hoʻopili i nā capsules vitamin D ma kahi ʻano melemele ʻAʻole pono ʻoe e ʻimi i kahi mamao e ʻike ai i nā ʻōlelo he maikaʻi ka lawe ʻana i nā mea hoʻohui huaʻai D no kou olakino. Manaʻo ʻia he mea maikaʻi ia no nā mea āpau mai ka pale ʻana i ka maʻi kanesa a me ka dementia a i ka pale ʻana i nā maʻi a me nā maʻi maʻi puʻuwai. ʻO ka mea pōʻino, ʻaʻole i hōʻoia ʻia ka nui o nā pono i manaʻo ʻia o nā mea hoʻohui vitamin D. Eia nō naʻe, lawe mau ka miliona o ka poʻe i ka vitamina D, me ka manaʻo e kōkua ia i ka pale ʻana i ka nui o nā maʻi, me kekahi mau maʻi autoimmune. Akā, hana? ʻO kahi haʻawina i hoʻopaʻa ʻia a hoʻopaʻa ʻia i paʻi ʻia ma The BMJ e nānā pono i kēlā nīnau.

No ke aha e pale ai ka huaora D i ka maʻi autoimmune?

ʻOiai ʻaʻole ʻike nui ʻia ke kumu o ka hapa nui o ka maʻi autoimmune, ʻo ka manaʻo alakaʻi ʻo ia ka hewa o ka hoʻoponopono ʻana i ka ʻōnaehana pale o ke kino. Mālama ka ʻōnaehana pale i ke kino mai nā mea ʻino e like me nā maʻi, a kōkua i ka hoʻoponopono ʻana i nā ʻiʻo i poino. Ke ulu ka maʻi autoimmune, hoʻouka ka ʻōnaehana pale i kona pūʻali. No ka laʻana, me ka rheumatoid arthritis, hoʻouka ʻia nā cell immune i nā hono, nā māmā, a me nā ʻāpana ʻē aʻe o ke kino. Ua hōʻike ʻia ka noiʻi e hiki i ka huaora D ke launa pū me nā cell immune, pili i nā genes e hoʻoponopono ai i ka mumū, a hoʻololi i ka pane o ka ʻōnaehana pale. No laila he mea maʻalahi ke noiʻi inā he ala maikaʻi ka vitamin D supplemental e mālama ai a pale paha i ka maʻi autoimmune. Ua kiʻi ka haʻawina BMJ i ka ʻikepili i hōʻiliʻili ʻia i ka wā o kahi hoʻokolokolo nui i paʻi ʻia i kekahi mau makahiki i hala. ʻOi aku ma mua o 25,000 poʻe ʻelemakule i hoʻokaʻawale ʻia e lawe

2,000 IU o ka huaʻai D a i ʻole kahi placebo like ʻole (palapala hana ʻole) i kēlā me kēia lā. (ʻOi aku kēia ma mua o ka nui o kēlā me kēia lā no nā pākeke, akā haʻahaʻa ma mua o ka palena kiʻekiʻe o 4,000 IU.)
1,000 mg o ka aila omega-3 a i ʻole kahi placebo like i kēlā me kēia lā.

Ma hope o ka awelika o ʻelima mau makahiki, ua helu ʻia nā maʻi hou o ka maʻi autoimmune ma waena o nā mea noiʻi.

He aha ka mea i loaʻa i ka haʻawina hou?

Aia paha ka pane ma kahi āu i lohe ai a heluhelu paha e pili ana i ka haʻawina BMJ . He ʻoiaʻiʻo ua ʻike ka poʻe noiʻi ʻo ka poʻe pākeke e lawe ana i nā mea hoʻohui huaʻai D he haʻahaʻa haʻahaʻa ka ulu ʻana o ka maʻi autoimmune. Akā eia ka ʻōlelo a kekahi o nā poʻomanaʻo nūhou i ʻoi aku ka hoihoi:

ʻO nā mea hoʻohui Vitamin D e hōʻemi maoli i ka pilikia o ka maʻi autoimmune ( New Scientist )
ʻO ka lawe ʻana i ka Vitamin D i kēlā me kēia lā ke kōkua i ka pale ʻana i kēia maʻi, wahi a ka haʻawina hou (E ʻai i kēia, ʻaʻole kēlā!)
ʻO ka lawe ʻana i ka huaora D a me ka omega-3 iʻa aila hoʻopiha i kēlā me kēia lā e hōʻemi i kou pilikia o ka hoʻomohala ʻana i ka maʻi maʻi e 22%, ʻōlelo ʻia e ka noiʻi
(Daily Mail)

He kani maikaʻi, pololei? Aka, he oiaio anei?

He aha ka mea e haʻi mai iā mākou i ka nānā ʻana i ka haʻawina?

Ua hōʻike nā mea noiʻi

Ua loaʻa i ka 123 poʻe e lawe ana i ka huaora D i ka maʻi autoimmune, i hoʻohālikelike ʻia me 155 mau kānaka i ka hui placebo. Hōʻike kēia i kahi hōʻemi 22%. Ua like ia me ka nui, akā ua hāʻule ka emi maoli o ka pilikia no ka hoʻomohala ʻana i kahi maʻi autoimmune mai kahi o 12 mau kānaka i 1,000 a i 9.5 mau kānaka ma 1,000.
Rheumatoid arthritis, polymyalgia rheumatica, a me psoriasis ka mea maʻamau. ʻAʻohe maʻi autoimmune hoʻokahi i pale pono ʻia e ka hoʻohui ʻana i ka vitamin D. ʻO ka manawa wale nō i hui pū ʻia nā helu o nā maʻi autoimmune a ʻike ka poʻe noiʻi i kahi pōmaikaʻi.
Ua ʻike ʻia ka pōmaikaʻi o ka huaora D i ka wā i nānā ʻia ai nā makahiki hope ʻekolu o ke aʻo ʻana. Hōʻike kēia i kahi manawa e loaʻa ai ka pōmaikaʻi mai kahi pākuʻi i kēlā me kēia lā.
ʻO ka poʻe i hāʻawi ʻia e loaʻa i ka omega-3 fatty acids ʻaʻole i loaʻa ka haʻahaʻa haʻahaʻa no ka maʻi autoimmune i hōʻoia ʻia.
He liʻiliʻi a like nā hopena ʻaoʻao i ka poʻe e lawe ana i nā mea hoʻohui a me nā mea lawe placebo.

ʻO kēia haʻawina randomized ʻo ia kekahi o nā mea maikaʻi loa e ʻimi i ka hopena o ka hoʻohui ʻana i ka vitamin D i ka pilikia o ka hoʻomohala ʻana i ka maʻi autoimmune. Akā ua hilinaʻi ka noiʻi ʻana i nā hihia i hōʻike ʻia iā ia iho, ma hope i hōʻoia ʻia e ka loiloi moʻolelo olakino. No laila, ua poina ʻia kekahi mau hihia o ka maʻi autoimmune. Eia kekahi, ʻo ka haʻawina i komo wale i nā poʻe ʻelemakule (awelika makahiki 67). He mea koʻikoʻi kēia no ka mea, hoʻomaka maʻamau kekahi o nā maʻi autoimmune maʻamau, e like me ka lupus a me ka rheumatoid arthritis, i ka wā ʻōpio. Ua ʻokoʻa paha nā hopena inā ua komo nā mea ʻōpio i ke aʻo ʻana.

Pono mākou a pau e lawe i nā mea hoʻohui vitamin D?

Ma muli o kēia haʻawina, ʻaʻole wau. Hoʻokahi mea, pono e hōʻoia kēia mau ʻike e nā mea noiʻi kūʻokoʻa ʻē aʻe. A ʻoiai nā poʻo poʻomanaʻo hoihoi loa, ʻo ka hōʻemi maoli ʻana he 2.5 mau hihia mai 1,000. Pono nā haneli o ka poʻe e lawe i ka vitamina D i kēlā me kēia lā no nā makahiki e pale ai i hoʻokahi hihia o ka maʻi autoimmune. Hiki i ka Vitamin D ke launa pū me nā lāʻau lapaʻau ʻē aʻe, a ʻo ka lawe ʻana i ka nui o ka huaora D he mea pōʻino.

ʻO ka laina lalo

He lāʻau lapaʻau palekana maoli anei ka huaora D i hiki ke pale a mālama paha i ka nui o nā maʻi? Ma muli o ka noiʻi o kēia manawa ʻaʻole maopopo, ʻoiai ke manaʻo nei au ʻoi aku ka maikaʻi o ka mālama ʻana i ka noʻonoʻo. Hiki iā mākou ke ʻike i ka mea liʻiliʻi o ka huaora D no ke kanaka maʻamau akā he mea maikaʻi loa ia no nā poʻe ʻē aʻe; ʻo ka ʻimi ʻana i ka mea e pōmaikaʻi ai. No ka laʻana, ʻoi aku ka maikaʻi o ka vitamin D hou no ka poʻe i loaʻa ka moʻolelo ʻohana ikaika o kekahi mau maʻi autoimmune. I kēia manawa, loaʻa iā mākou ka mokuna hou loa o ka moʻolelo o ka huaora D. ʻO ka noiʻi e hiki mai ana e hōʻike i ka hopena ʻokoʻa a i ʻole ka hoʻokumu ʻana o ka huaora D i mea e pono ai. ʻO ka mea nui paha, ʻo kēia haʻawina a me nā mea ʻē aʻe e hiki mai ana e hiki ke hāʻawi i kahi ʻike maikaʻi aʻe i ke kuleana o ka vitamina D i ka hoʻomohala ʻana i nā maʻi autoimmune. E hahai mai iaʻu ma Twitter @RobShmerling ʻO ke kumukūʻai no kahi ʻōnaehana pale makaʻala e hiki ke hoʻopaʻa i nā pūnaewele a i ʻole pathogens he ahi aloha i kekahi manawa – he hoʻouka autoimmune. Ua ʻike ka poʻe ʻepekema i kahi ʻano hou o ke kelepona T kanaka e hoʻopau ana i ka hoʻouka ʻana i nā ʻiʻo olakino, kahi ʻike e hiki ke hōʻike i nā lāʻau lapaʻau no nā kūlana like ʻole e like me ka lupus a me ka maʻi kanesa. “He hana nui ia i mua o ka hoʻomaopopo ʻana i ke ʻano o ka hoʻoponopono ʻana i ka pane a me ka autoimmunity,” wahi a ka immunologist Harvey Cantor o ka Dana-Farber Cancer Institute, ʻaʻole i komo i ka hana. Ua ʻike mua ka poʻe Immunologists i nā ʻiole a ua hoʻohana nā kānaka i hoʻokahi ʻano o ke kelepona T hoʻoponopono – kahi ʻāpana i kapa ʻia ʻo Tregs e pāʻani ana i ka protein CD4-a hoʻopaʻa i nā hōʻeha autoimmune. Aia nā mea hoʻokō hou i kahi ʻano o nā pūnae T i ʻike ʻia e kahi protein honua ʻē aʻe, CD8. ʻIke maikaʻi ʻia nā pūnae CD8 T no ka pepehi ʻana i nā maʻi maʻi a i ʻole nā pūnaewele maʻi kanesa, akā i nā ʻiole, pepehi pū kekahi o lākou i nā pūnae T e hoʻolalelale i nā hopena autoimmune. ʻOiai ua manaʻo lōʻihi ka poʻe noiʻi i loaʻa i ke kanaka nā cell like, ʻaʻohe mea i hōʻoia i ko lākou ola ʻana. ʻO kekahi mea keakea, ʻaʻole hana ke kanaka i nā ʻokoʻa kūʻokoʻa e hōʻailona ai i ka subset o nā cell CD8 i nā ʻiole. Eia nō naʻe, ʻo kekahi mau pūnaewele CD8 T kanaka e hōʻike aku i nā mea hoʻokipa like, nā protein KIR. No ka hoʻoholo ʻana inā he mau mea pale ʻole kēia mau keena kanaka, ʻo Jing Li, he postdoc i loko o ka lab o immunologist Mark Davis ma ke Kula Lapaʻau ʻo Stanford University, a ua ana nā hoa hana i kā lākou nui i nā maʻi me nā maʻi autoimmune e like me ka maʻi sclerosis, lupus, a me ka maʻi celiac. Uaʻoi aku ka maʻamau o nā pūnaewele i ke koko mai nā maʻi ma mua o ke koko mai nā kānaka olakino, hōʻike ka hui ma ka pūnaewele i kēia lā ma Science . Ua hōʻike ʻia nā ʻano kikoʻī ua ʻākoakoa lākou i nā ʻāpana o ke kino i hōʻino ʻia e ka hōʻeha autoimmune, e like me nā hui o ka poʻe me ka rheumatoid arthritis a me ka ʻōpū liʻiliʻi i ka poʻe me ka maʻi celiac. Ua ʻike ka poʻe noiʻi i nā piʻi like ʻana o nā cell T e hana ana i ka KIR i ka poʻe e hakakā nei i nā maʻi, ʻoi aku ka maʻi maʻi coronavirus. I nā maʻi maʻi 56 COVID-19, “Ua ʻike mākou i nā cell KIR-positive e hele ana ma ka hale,” wahi a Davis. A ʻo nā mea maʻi maʻi COVID-19, ʻoi aku ka nui o nā cell a lākou i hoʻopaʻa ai. Piʻi aʻe ka helu o nā cell i nā maʻi me ka maʻi influenza, ʻike ka hui. No ka noiʻi ʻana i ke kuleana o nā cell i ka autoimmunity, ua noho nā ʻepekema i ka maʻi celiac, ka mea i hoʻoulu ʻia e nā protein gluten i ka berena a me nā meaʻai ʻē aʻe. I nā poʻe maʻi me kēia maʻi, i kapa ʻia ʻo helper T cell e ʻike i nā protein gluten e like me gliadin a laila hoʻokahe i nā molekala e hoʻoikaika i ka mumū. Akā, i loko o nā haʻawina moʻomeheu cell, ua ʻike ʻo Li a me nā hoa hana, ua pepehi ʻia nā pūnaewele CD8 T kanaka e lawe ana i nā protein KIR i nā cell T helper e ʻike ana i ka gliadin. “Ua wehe maoli ia i ka puka makani no mākou e hoʻomaopopo i ka biology o kēia mau cell [KIR+],” wahi a Li. No ka ʻike ʻana i ka nui o ka pale ʻana o nā cell mai ka autoimmunity, ua ʻimi ʻo Li a me kāna mau hoa hana i nā ʻiole genetically hoʻololi ʻia he 50% a 75% ka liʻiliʻi o nā cell CD8 suppressive ma mua o ka maʻamau. Ma hope o ka ʻike ʻana i kekahi mau maʻi e hiki ai ke hoʻoulu i ka maʻi autoimmune, ua hoʻomohala nā rodents i nā hōʻailona o ka pōʻino e like me ka ʻāʻī ʻana. ʻO ka hoʻokaʻawale ʻana, ʻaʻole i hōʻike ʻia nā ʻiole hoʻomalu me ka hoʻopiha piha o nā pūnae CD8 T suppressive i nā maʻi autoimmune ma hope o nā maʻi. Manaʻo ʻo Cantor a me nā kānaka ʻepekema ʻē aʻe ua hoʻopaʻa lima ka hui i nā hoa kanaka i ʻimi lōʻihi ʻia i ka rodent immune regulators. “Hāʻawi ka pepa i ka ʻikepili paʻa loa e noho nei kēia mau cell i loko o ke kanaka,” wahi a ka immunologist Nu Zhang o ke Kulanui o Texas Health Science Center, San Antonio. Ua pohihihi paha lākou no ka mea “he kakaikahi lākou a ua maʻalahi ka nalo ʻana,” no ka helu wale ʻana ma kahi o 5% o nā cell T CD8 maikaʻi, wahi a Davis. Ua ʻōlelo ʻo Immunologist Stephen Jameson o ke Kula Lapaʻau o ke Kulanui o Minnesota, ʻo nā ala e hoʻonui ai i ka nui o nā cell e kōkua i ka hōʻoluʻolu i nā maʻi autoimmune paʻakikī e like me ka maʻi celiac. Hiki nō hoʻi, hoʻohui ʻo ia, ke “noho nei nā cell i loko o nā ʻōpū” a pale iā lākou mai nā hoʻouka kaua ʻana, a ma ia hihia e hōʻemi ana i nā cell ‘hiki ke hoʻokuʻu i ka ʻōnaehana pale o ke kanaka e hakakā i ka maʻi kanesa. Ua hoʻāʻo ka poʻe noiʻi e hoʻohana i nā Tregs maʻamau, lawe CD4 no nā lāʻau lapaʻau, akā ʻaʻole i ʻae ʻia nā lāʻau lapaʻau, wahi a Cantor. “ʻO ka manaʻolana me kēia pūʻulu hoʻoponopono hou, hiki iā mākou ke hoʻohana pono iā lākou.” ʻO kahi nīnau koʻikoʻi no ke aha e pono ai ka ʻōnaehana pale i kahi ʻano ʻē aʻe o ke kelepona T suppressive inā loaʻa iā Tregs. Akā ʻo Tregs nā mea maʻamau e kāohi i nā ʻano o nā cell immune me ka pepehi ʻole iā lākou. Manaʻo ʻo Davis i ka KIR-positive CD8 e hoʻopaʻa i nā cell T i hoʻololi ʻia i ka wā o ka hoʻouka ʻana e kahi pathogen. ʻOiai ke kōkua nei kēia mau pūnaewele T hou i ka hoʻomaʻemaʻe ʻana i nā mea hoʻouka kaua, hiki iā lākou ke hoʻouka i nā ʻiʻo olakino. Ke lawelawe nei ka subclass KIR ma ke ʻano he “SWAT team” e pepehi i kēia mau keena T hiki ke hoʻopau ʻia ke hoʻopau ʻia kahi maʻi, ʻōlelo ʻo Davis. ʻO ka pahū ʻana o nā cell CD8 T maikaʻi KIR i ʻike ʻia e nā mea noiʻi i nā mea maʻi me nā maʻi autoimmune a i ʻole COVID-19 e hōʻike i kahi hoʻāʻo e hoʻihoʻi hou i nā hopena kūlohelohe – ʻo ka overreaction immune i ka novel coronavirus ka mea e pepehi ai i nā mea maʻi he nui COVID-19 i ka hopena. . ʻO ke ʻano o ka hoʻokaʻawale ʻana o nā cell CD8 suppressive i nā pūnaewele T me nā manaʻo hoʻopōʻino iā ia iho kekahi o nā mea pohihihi e pono ai nā ʻepekema e pane. Hoʻopilikia ka maʻi autoimmune i 23.5 miliona ʻAmelika, a kokoke i ka 80 pakeneka o ia mau wahine. Inā ʻo ʻoe kekahi o ka miliona o nā wahine i hoʻopilikia ʻia e kēia hui o nā maʻi, ʻo ia hoʻi ka lupus, ka rheumatoid arthritis a me ka maʻi thyroid, e noʻonoʻo paha ʻoe i ke kumu e hoʻouka ai kāu ʻōnaehana pale iā ia iho. ʻO Ana-Maria Orbai, MD, MHS, he rheumatologist ma Johns Hopkins Arthritis Center. Hoʻomaʻamaʻa ka poʻe Rheumatologists i ka ʻike ʻana a me ka mālama ʻana i nā maʻi musculoskeletal a me nā kūlana autoimmune (maʻi rumatika). Ua wehewehe ʻo Orbai i kekahi mau manaʻo a ka poʻe noiʻi e pili ana i ka mea e hoʻoulu ai i ka maʻi autoimmune, me ka maʻi, ka pōʻino o ka ʻiʻo a me nā genetics.

ʻO ka loulou ma waena o ka maʻi autoimmune a me nā wahine

ʻAʻole maopopo i nā kauka ke kumu o ka loaʻa ʻana o ka maʻi autoimmune ma kahi mua a i ʻole ke kumu o ka hopena o nā wahine ma mua o nā kāne. ʻO kekahi manaʻo ʻo ia ke kiʻekiʻe o nā hormones i loko o nā wahine, ʻoi aku hoʻi i nā makahiki hānau keiki, hiki i nā wahine ke maʻalahi i nā maʻi autoimmune. Eia nō naʻe, ʻike ʻo Orbai ʻaʻole i hōʻoia ʻia kēia manaʻo – he nui nā mea e pili ana i ka autoimmunity, ʻo ka genetic a me ke kaiapuni. ʻAʻole hiki i nā mea noiʻi ke wehewehe pono i ke kumu e ulu ai nā wahine i kēia mau maʻi ma mua o nā kāne.

ʻO ke kuleana o ka maʻi a me ka maʻi

Ma kahi pae kumu, hiki mai ka maʻi autoimmune no ka mea ʻo nā pale kūlohelohe o ke kino – ka ʻōnaehana pale – hoʻouka i ke kino olakino ponoʻī. Nui nā manaʻo o ka poʻe noiʻi e pili ana i ke kumu o kēia. Ke ʻike ke kino i ka pōʻino mai ka maʻi maʻi a i ʻole ka maʻi maʻi, hoʻomaka ka ʻōnaehana pale i ka mīkini a hoʻouka iā ia. Kapa ʻia kēia he pane immune. I kekahi manawa, paʻa nā pūnaewele olakino a me nā ʻiʻo i kēia pane, ka hopena i ka maʻi autoimmune. Manaʻo ka nui o nā ʻepekema ʻo ia ke kumu o ka rheumatoid arthritis, kahi ʻano o ka maʻi autoimmune e hoʻouka i nā ami. He mea maʻamau nō hoʻi ma hope o ka loaʻa ʻana o ka puʻu strep, hoʻomohala ka poʻe i ka psoriasis, kahi maʻi autoimmune e hoʻoulu ai i nā ʻāpana o ka ʻili mānoanoa. Hiki mai nā ʻano maʻi autoimmune ʻē aʻe mai ke kino e hoʻāʻo nei e kaua kūʻē i nā maʻi maʻi maʻi. Kuhi ʻo Orbai i ka scleroderma, kahi maʻi e mānoanoa ai ka ʻili a me nā ʻiʻo pili. “ʻO ka manaʻo ʻo ia ke hoʻopau ʻia ka ʻōnaehana pale i ka maʻi kanesa, aia kahi pane inflammatory koena ma muli o kēlā hakakā,” wahi āna. Ua aʻo nā kānaka noiʻi Johns Hopkins i nā maʻi i hoʻomohala i ka scleroderma a me ka maʻi kanesa e hoʻāʻo e wehewehe i kēia pilina.

Ka Manao Poino

Manaʻo ka poʻe ʻepekema hiki i ka ʻeha ke hana i kekahi ʻano o ka maʻi autoimmune e like me ka psoriatic arthritis, kahi maʻi e pili ana i nā ami o kekahi poʻe me psoriasis. Ua hōʻike ʻia ka noiʻi ʻana ma nā ʻāpana o ke kino i hoʻokau ʻia i ke koʻikoʻi kiʻekiʻe, loaʻa kahi pane autoimmune ma hope o ka pōʻino i nā tendons, kahi e hoʻopili ai i ka ʻiʻo i ka iwi. ʻO kahi laʻana, ʻo ka kuʻekuʻe wāwae he wahi kahi e huki mau ai ka ʻiʻo i ka iwi e hana i ka neʻe. “Hiki i kēia koʻikoʻi pinepine ke hōʻike i ka ʻiʻo ʻaʻole pono e hoʻopili maʻamau me nā ʻāpana koko,” wahi a Orbai. “Ke ʻike ʻia kēlā ʻiʻo, ua like ia me kahi ʻeha liʻiliʻi. Ke hoʻāʻo nei nā ʻāpana koko e hoʻōla iā ia, akā ʻo ka pane ʻole ʻana o ke kino e hoʻoulu ai i ka mumū o nā hono a me nā tendon. Hoʻomaopopo koke ʻo Orbai ʻoiai aia kekahi mau ʻikepili e kākoʻo iā lākou, ʻaʻole i hōʻoia nā ʻepekema ʻo ia nā kumu o ka maʻi autoimmune.

Pilikia Genetic

Ua maopopo he kuleana ko genetics i ka maʻi autoimmune, akā ʻaʻole maopopo ka poʻe noiʻi pehea. No ka laʻana, ʻo ka loaʻa ʻana o kahi lālā o ka ʻohana me ka lupus a i ʻole ka maʻi sclerosis (MS) e hoʻonui i kou pilikia e loaʻa i kēia mau maʻi. Nui nā lālā o kekahi mau ʻohana i nā maʻi autoimmune like ʻole. Akā naʻe, ʻaʻole lawa ka genetics wale nō e hoʻoulu ai i ka maʻi autoimmune. “Ua ʻike mākou he mea nui nā genes, akā ʻaʻole ia nā mea āpau,” wahi a Orbai. “Hiki iā ʻoe ke loaʻa nā ʻohana me ka lupus a i ʻole MS a ʻaʻole loaʻa iā ʻoe iho. Hiki iā ʻoe ke hoʻāʻo i ka maikaʻi no ka DNA lupus-specific a ʻaʻole loaʻa ka maʻi. ” Hiki paha i ka maʻi autoimmune ma muli o ka hiki i ka ʻōnaehana pale ke mālama i ke kaumaha. Wahi a Orbai he wahi kēia o ka noiʻi ikaika. “I ka manawa hea e ʻoi aku ai ke koʻikoʻi o kou kino ma mua o ka hiki i kāu ʻōnaehana pale ke mālama iā ia? Inā ʻike mākou i kēia, ʻo ia ke kī i ka pale ʻana i ka maʻi autoimmune ma mua o ka ulu ʻana.

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